| 2. Jornada | 16.07.2022 | Real Cartagena | - | Leones FC | 0:1 | ||||
| 3. Jornada | 22.07.2022 | Atlético Huila | - | Real Cartagena | 2:3 | ||||
| 4. Jornada | 29.07.2022 | Real Cartagena | - | Cúcuta Deportivo | 1:2 | ||||
| 7. Jornada | 17.08.2022 | Real Cartagena | - | Real Santander | 2:2 | ||||
| 12. Jornada | 11.09.2022 | Llaneros FC | - | Real Cartagena | 2:0 | ||||
| 1. Jornada | 15.09.2022 | Atlético FC | - | Real Cartagena | 0:2 | ||||
| 13. Jornada | 20.09.2022 | Real Cartagena | - | Deportes Quindío | 3:1 | ||||
| 14. Jornada | 25.09.2022 | Barranquilla FC | - | Real Cartagena | 2:3 |  |
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| 15. Jornada | 01.10.2022 | Real Cartagena | - | Boca Juniors de Cali | 0:0 | ||||
| 16. Jornada | 08.10.2022 | Bogotá FC | - | Real Cartagena | 2:0 |
Colombia