| Segunda etapa | 07.04.2022 | Louisville City FC | - | Chattanooga Red Wolves | 1:0 |  |
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| Tercera ronda | 21.04.2022 | Louisville City FC | - | St. Louis City SC 2 | 9:8 pn. | ||||
| Cuarta Ronda | 11.05.2022 | Detroit City FC | - | Louisville City FC | 2:4 pn. | |
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| Octavos de final | 26.05.2022 | Louisville City FC | - | Nashville SC | 1:2 |
Estados Unidos