| 1. Jornada | 16.10.2020 | General Díaz | - | San Lorenzo | 0:1 | ||||
| 2. Jornada | 25.10.2020 | San Lorenzo | - | Club Nacional | 1:1 | ||||
| 3. Jornada | 02.11.2020 | Club Olimpia | - | San Lorenzo | 3:1 | ||||
| 4. Jornada | 06.11.2020 | 12 de Octubre de Itauguá | - | San Lorenzo | 0:1 | ||||
| 5. Jornada | 12.11.2020 | San Lorenzo | - | Sportivo Luqueño | 1:2 | ||||
| 6. Jornada | 17.11.2020 | Guaraní | - | San Lorenzo | 2:1 |  |
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| 7. Jornada | 21.11.2020 | San Lorenzo | - | Libertad | 2:2 | ||||
| 8. Jornada | 28.11.2020 | Guaireña FC | - | San Lorenzo | 2:2 | ||||
| 9. Jornada | 06.12.2020 | San Lorenzo | - | Sol de América | 2:2 | |
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| 10. Jornada | 14.12.2020 | Cerro Porteño | - | San Lorenzo | 1:1 | ||||
| 11. Jornada | 18.12.2020 | San Lorenzo | - | River Plate | 0:0 |
Paraguay