| 1. Jornada | 14.01.2023 | UD Universitario | - | San Francisco FC | 0:1 |  |
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| 2. Jornada | 21.01.2023 | UMECIT | - | San Francisco FC | 1:1 |  |
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| 3. Jornada | 28.01.2023 | San Francisco FC | - | Independiente de La Chorrera | 2:2 | |
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| 4. Jornada | 04.02.2023 | San Francisco FC | - | Herrera FC | 0:0 | ||||
| 5. Jornada | 11.02.2023 | Atlético Chiriquí | - | San Francisco FC | 3:1 | |
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| 6. Jornada | 15.02.2023 | San Francisco FC | - | Potros del Este | 1:3 | ||||
| 7. Jornada | 25.02.2023 | San Francisco FC | - | Sporting San Miguelito | 1:1 | ||||
| 8. Jornada | 04.03.2023 | San Francisco FC | - | Plaza Amador | 1:1 | ||||
| 9. Jornada | 12.03.2023 | Tauro FC | - | San Francisco FC | 2:0 | ||||
| 10. Jornada | 20.03.2023 | Alianza | - | San Francisco FC | 0:0 | ||||
| 11. Jornada | 25.03.2023 | Árabe Unido | - | San Francisco FC | 0:0 | ||||
| 12. Jornada | 01.04.2023 | San Francisco FC | - | UD Universitario | 2:1 | ||||
| 13. Jornada | 05.04.2023 | San Francisco FC | - | UMECIT | 0:0 | ||||
| 14. Jornada | 15.04.2023 | Independiente de La Chorrera | - | San Francisco FC | 3:0 |
Panamá