| Zona B | 21.02.2021 | Cobán Imperial | - | CSD Municipal | 1:0 | ||||
| Zona B | 28.02.2021 | Achuapa | - | Cobán Imperial | 2:1 | ||||
| Zona B | 06.03.2021 | Cobán Imperial | - | Sanarate | 2:0 | ||||
| Zona B | 10.03.2021 | Deportivo Guastatoya | - | Cobán Imperial | 1:1 | ||||
| Zona B | 13.03.2021 | CSD Municipal | - | Cobán Imperial | 2:0 | ||||
| Zona B | 31.03.2021 | Cobán Imperial | - | Achuapa | 3:2 |  |
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| Zona B | 04.04.2021 | Sacachispas | - | Cobán Imperial | 1:2 |  |
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| Zona B | 07.04.2021 | Sanarate | - | Cobán Imperial | 0:0 | ||||
| Zona B | 10.04.2021 | Cobán Imperial | - | Deportivo Guastatoya | 0:1 | ||||
| Interzona | 14.04.2021 | Cobán Imperial | - | Iztapa | 2:2 | |
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| Interzona | 17.04.2021 | Santa Lucía | - | Cobán Imperial | 1:1 | |
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| Interzona | 21.04.2021 | Cobán Imperial | - | Xelaju MC | 0:0 | ||||
| Interzona | 25.04.2021 | Deportivo Malacateco | - | Cobán Imperial | 0:0 | ||||
| Interzona | 28.04.2021 | Cobán Imperial | - | Antigua GFC | 4:2 | ||||
| Interzona | 02.05.2021 | Comunicaciones | - | Cobán Imperial | 1:1 | ||||
| Cuartos de final | 06.05.2021 | Cobán Imperial | - | Santa Lucía | 1:1 | ||||
| Cuartos de final | 09.05.2021 | Santa Lucía | - | Cobán Imperial | 3:0 |
Guatemala