| 5. Jornada | 20.02.2022 | Atlético Huila | - | Real Santander | 1:1 | ||||
| 8. Jornada | 10.03.2022 | Atlético FC | - | Real Santander | 0:1 | ||||
| 9. Jornada | 21.03.2022 | Real Santander | - | Leones FC | 0:4 | ||||
| 10. Jornada | 26.03.2022 | Bogotá FC | - | Real Santander | 2:1 | ||||
| 11. Jornada | 03.04.2022 | Real Santander | - | Orsomarso SC | 0:0 | ||||
| 12. Jornada | 10.04.2022 | Llaneros FC | - | Real Santander | 2:2 |
Colombia