| 1. Jornada | 18.02.2021 | Real Santander | - | Atlético Huila | 2:2 | ||||
| 7. Jornada | 21.02.2021 | Real Santander | - | Unión Magdalena | 0:1 |  |
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| 2. Jornada | 24.02.2021 | Cortuluá | - | Real Santander | 1:0 | |
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| 8. Jornada | 01.03.2021 | Real Santander | - | Deportes Quindío | 1:1 | ||||
| 9. Jornada | 04.03.2021 | Real Santander | - | Orsomarso SC | 1:2 | ||||
| 10. Jornada | 07.03.2021 | Real Santander | - | Boca Juniors de Cali | 0:1 | ||||
| 14. Jornada | 03.04.2021 | Real Santander | - | Fortaleza FC | 3:1 | ||||
| 15. Jornada | 09.04.2021 | Leones FC | - | Real Santander | 2:0 |
Colombia