| 1. Jornada | 09.07.2022 | Real Santander | - | Llaneros FC | 3:1 | ||||
| 3. Jornada | 23.07.2022 | Real Santander | - | Fortaleza FC | 1:0 | ||||
| 5. Jornada | 05.08.2022 | Leones FC | - | Real Santander | 1:1 |  |
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| 6. Jornada | 08.08.2022 | Real Santander | - | Bogotá FC | 2:0 | ||||
| 7. Jornada | 17.08.2022 | Real Cartagena | - | Real Santander | 2:2 | |
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| 8. Jornada | 20.08.2022 | Orsomarso SC | - | Real Santander | 0:0 | ||||
| 9. Jornada | 27.08.2022 | Real Santander | - | Cúcuta Deportivo | 0:1 | |
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| 10. Jornada | 03.09.2022 | Tigres FC | - | Real Santander | 2:2 | ||||
| 13. Jornada | 19.09.2022 | Real Santander | - | Boyacá Chicó | 0:0 |
Colombia