| 1. Jornada | 24.07.2021 | FK Jablonec | - | Baník Ostrava | 1:0 | ||||
| 2. Jornada | 01.08.2021 | Baník Ostrava | - | FC Fastav Zlín | 5:1 |  |
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| 3. Jornada | 07.08.2021 | Dynamo České Budějovice | - | Baník Ostrava | 1:3 | ||||
| 4. Jornada | 15.08.2021 | Baník Ostrava | - | FK Pardubice | 3:1 | ||||
| 5. Jornada | 22.08.2021 | Slavia Praga | - | Baník Ostrava | 4:0 | ||||
| 6. Jornada | 28.08.2021 | Baník Ostrava | - | FK Mladá Boleslav | 1:0 |  |
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| 7. Jornada | 11.09.2021 | FK Teplice | - | Baník Ostrava | 1:2 | |
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| 8. Jornada | 17.09.2021 | Sigma Olomouc | - | Baník Ostrava | 1:1 | |
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| 9. Jornada | 25.09.2021 | Baník Ostrava | - | Bohemians Praha 1905 | 4:1 | ||||
| 13. Jornada | 31.10.2021 | Baník Ostrava | - | Sparta Praga | 2:2 | |
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| 15. Jornada | 20.11.2021 | Baník Ostrava | - | Viktoria Plzeň | 2:2 | ||||
| 12. Jornada | 24.11.2021 | MFK Karviná | - | Baník Ostrava | 1:2 | |
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| 16. Jornada | 27.11.2021 | FC Fastav Zlín | - | Baník Ostrava | 2:2 | ||||
| 17. Jornada | 05.12.2021 | Baník Ostrava | - | Dynamo České Budějovice | 4:1 | ||||
| 18. Jornada | 11.12.2021 | FK Pardubice | - | Baník Ostrava | 0:3 | |
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| 19. Jornada | 19.12.2021 | Baník Ostrava | - | Slavia Praga | 3:3 |
Nigeria