| 1. Jornada | 24.07.2021 | Havre AC | - | Guingamp | 0:0 | ||||
| 2. Jornada | 31.07.2021 | Guingamp | - | Valenciennes FC | 1:1 | ||||
| 3. Jornada | 07.08.2021 | Grenoble Foot 38 | - | Guingamp | 0:0 |  |
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| 5. Jornada | 23.08.2021 | AJ Auxerre | - | Guingamp | 1:2 | ||||
| 6. Jornada | 28.08.2021 | Guingamp | - | AC Ajaccio | 1:1 | ||||
| 7. Jornada | 11.09.2021 | Paris FC | - | Guingamp | 0:1 | ||||
| 8. Jornada | 18.09.2021 | Chamois Niortais | - | Guingamp | 2:0 | ||||
| 15. Jornada | 06.11.2021 | Guingamp | - | Bastia | 2:3 | ||||
| 22. Jornada | 22.01.2022 | Amiens SC | - | Guingamp | 3:0 | ||||
| 35. Jornada | 22.04.2022 | Dijon FCO | - | Guingamp | 3:3 | ||||
| 37. Jornada | 07.05.2022 | USL Dunkerque | - | Guingamp | 1:3 | ||||
| 38. Jornada | 14.05.2022 | Guingamp | - | Havre AC | 2:1 |
Francia
R.D. Congo