Segunda etapa
14.09.2021 15:00 FC Olimpia - FC Sîngerei 1:3
15:00 CS Cruiz-Plus - FCM Ungheni 1:4
15:00 ARF Ocniţa - Speranța Drochia 0:4
15:00 FC Real-Succes - Olimp Comrat 1:8
15:00 FC Saxan - Sporting Trestieni 3:2 pró.
15:00 FC Maiak Chirsova - FC Cahul 2005 2:4
15:00 Spartanii Sportul - Dacia Buiucani 2:0 pró.
15:00 CF Soroca - Victoria Bardar 0:1
Octavos de final
26.10.2021 12:00 FC Sfîntul Gheorghe - Victoria Bardar 1:0
12:00 CS Petrocub - Olimp Comrat 6:0
12:00 Spartanii Sportul - Dinamo-Auto 1:3
14:00 FC Bălţi - FC Cahul 2005 3:0
27.10.2021 12:00 FC Floreşti - FC Sîngerei 3:1
12:00 Speranța Drochia - FC Zimbru 1:4
14:00 FC Milsami - FCM Ungheni 5:1
14:00 FC Sheriff - FC Saxan 6:0
Cuartos de final
12.04.2022 FC Sfîntul Gheorghe - FC Floreşti 3:0
17:00 FC Sheriff - CS Petrocub 4:0
13.04.2022 15:00 FC Zimbru - FC Milsami 0:3
17:00 FC Bălţi - Dinamo-Auto 3:4 pn.
Semifinales
26.04.2022 15:00 Dinamo-Auto - FC Sheriff 2:3
18:00 FC Milsami - FC Sfîntul Gheorghe 0:2
Final
21.05.2022 19:00 FC Sfîntul Gheorghe - FC Sheriff 0:1 (0:0)
Cupa Moldova
Cupa Moldova