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| I | Flamurtari Vlorë | - | FK Vllaznia | 1:2 | ||
| V | FK Vllaznia | - | Flamurtari Vlorë | 1:0 | ||
| I: 26.01.2022 13:45 | V: 10.02.2022 13:45 | Campeones: FK Vllaznia | ||||
| I | Egnatia Rrogozhine | - | KF Laçi | 1:1 | ||
| V | KF Laçi | - | Egnatia Rrogozhine | 3:2 pn. | ||
| I: 26.01.2022 13:45 | V: 10.02.2022 13:45 | Campeones: KF Laçi | ||||
| I | KF Skënderbeu | - | KF Teuta Durrës | 0:1 | ||
| V | KF Teuta Durrës | - | KF Skënderbeu | 1:0 (1:0) | ||
| I: 27.01.2022 14:25 | V: 09.02.2022 16:45 | Campeones: KF Teuta Durrës | ||||
| I | Dinamo Tiranë | - | FK Partizani | 1:1 | ||
| V | FK Partizani | - | Dinamo Tiranë | 1:0 | ||
| I: 27.01.2022 16:45 | V: 10.02.2022 18:00 | Campeones: FK Partizani | ||||
