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| 31.01.2022 | 19:30 | SK Beveren II | - | RFC Seraing II | 0:1 | |
| 19:30 | KV Kortrijk II | - | KAS Eupen II | 2:3 | ||
| 20:00 | KVC Westerlo II | - | Excelsior Virton II | 3:5 | ||
| 20:00 | Lommel SK II | - | RWDM Brussels FC II | 3:2 | ||
| 20:00 | Lierse Kempenzonen II | - | Union St. Gilloise II | 0:3 | ||
| 20:00 | K Beerschot VA II | - | KV Oostende II | 3:3 | ||
| 28.02.2022 | 20:00 | SK Deinze II | - | Royal Excel Mouscron II | 0:3 |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KAS Eupen II | 17 | 13 | 1 | 3 | 44:20 | 24 | 40 |
| 2 |
|
K Beerschot VA II | 17 | 11 | 4 | 2 | 44:18 | 26 | 37 |
| 3 |
|
KV Oostende II | 17 | 8 | 7 | 2 | 43:23 | 20 | 31 |
| 4 |
|
SK Beveren II | 17 | 9 | 1 | 7 | 31:18 | 13 | 28 |
| 5 |
|
Royal Excel Mouscron II | 17 | 8 | 3 | 6 | 34:19 | 15 | 27 |
| 6 |
|
Union St. Gilloise II | 17 | 8 | 3 | 6 | 25:17 | 8 | 27 |
| 7 |
|
RWDM Brussels FC II | 17 | 8 | 2 | 7 | 41:38 | 3 | 26 |
| 8 |
|
Excelsior Virton II | 17 | 8 | 2 | 7 | 37:44 | -7 | 26 |
| 9 |
|
KVC Westerlo II | 17 | 6 | 2 | 9 | 27:32 | -5 | 20 |
| 10 |
|
Lierse Kempenzonen II | 17 | 5 | 4 | 8 | 20:41 | -21 | 19 |
| 11 |
|
RFC Seraing II | 17 | 6 | 0 | 11 | 24:34 | -10 | 18 |
| 12 |
|
SK Deinze II | 17 | 5 | 3 | 9 | 19:37 | -18 | 18 |
| 13 |
|
Lommel SK II | 17 | 3 | 3 | 11 | 15:40 | -25 | 12 |
| 14 |
|
KV Kortrijk II | 17 | 1 | 5 | 11 | 18:41 | -23 | 8 |
| Ascenso |
