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| 07.03.2022 | 19:30 | SK Beveren II | - | Union St. Gilloise II | 0:1 | |
| 19:30 | Royal Excel Mouscron II | - | Excelsior Virton II | 3:4 | ||
| 19:30 | KV Kortrijk II | - | RWDM Brussels FC II | 1:3 | ||
| 20:00 | SK Deinze II | - | Lommel SK II | 0:1 | ||
| 20:00 | RFC Seraing II | - | KAS Eupen II | 0:0 | ||
| 20:00 | Lierse Kempenzonen II | - | K Beerschot VA II | 0:3 | ||
| 20:00 | KVC Westerlo II | - | KV Oostende II | 1:2 |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
K Beerschot VA II | 21 | 15 | 4 | 2 | 54:18 | 36 | 49 |
| 2 |
|
KAS Eupen II | 21 | 15 | 2 | 4 | 50:24 | 26 | 47 |
| 3 |
|
KV Oostende II | 21 | 11 | 7 | 3 | 51:27 | 24 | 40 |
| 4 |
|
Excelsior Virton II | 21 | 11 | 2 | 8 | 50:52 | -2 | 35 |
| 5 |
|
Royal Excel Mouscron II | 21 | 10 | 4 | 7 | 44:25 | 19 | 34 |
| 6 |
|
SK Beveren II | 21 | 11 | 1 | 9 | 37:23 | 14 | 34 |
| 7 |
|
Union St. Gilloise II | 21 | 10 | 4 | 7 | 30:21 | 9 | 34 |
| 8 |
|
RWDM Brussels FC II | 21 | 9 | 2 | 10 | 44:45 | -1 | 29 |
| 9 |
|
KVC Westerlo II | 21 | 8 | 2 | 11 | 34:39 | -5 | 26 |
| 10 |
|
RFC Seraing II | 21 | 8 | 2 | 11 | 29:36 | -7 | 26 |
| 11 |
|
Lierse Kempenzonen II | 21 | 6 | 4 | 11 | 25:52 | -27 | 22 |
| 12 |
|
SK Deinze II | 21 | 5 | 3 | 13 | 21:46 | -25 | 18 |
| 13 |
|
Lommel SK II | 21 | 4 | 3 | 14 | 19:50 | -31 | 15 |
| 14 |
|
KV Kortrijk II | 21 | 1 | 6 | 14 | 23:53 | -30 | 9 |
| Ascenso |
