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| 02.04.2022 | 00:00 | Nacional Potosí | - | Club Aurora | 2:1 (0:1) | |
| 02:30 | Blooming | - | Always Ready | 1:0 (1:0) | ||
| 21:00 | Real Santa Cruz | - | Oriente Petrolero | 2:1 (0:1) | ||
| 21:00 | Universitario de Vinto | - | Independiente Petrolero | 2:2 (0:2) | ||
| 23:15 | Jorge Wilstermann | - | Real Tomayapo | 1:2 (1:2) | ||
| 03.04.2022 | 01:30 | Universitario de Sucre | - | Atlético Palmaflor | 2:0 (1:0) | |
| 21:00 | CD Guabirá | - | The Strongest | 1:3 (0:0) | ||
| 23:15 | Bolívar | - | Royal Pari | 6:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Nacional Potosí | 7 | 4 | 2 | 1 | 16:8 | 8 | 14 |
| 2 |
|
The Strongest | 7 | 4 | 2 | 1 | 12:5 | 7 | 14 |
| 3 |
|
Atlético Palmaflor | 7 | 4 | 1 | 2 | 7:8 | -1 | 13 |
| 4 |
|
Universitario de Sucre | 7 | 3 | 2 | 2 | 10:8 | 2 | 11 |
| 5 |
|
Oriente Petrolero | 7 | 3 | 0 | 4 | 8:9 | -1 | 9 |
| 6 |
|
Club Aurora | 7 | 1 | 3 | 3 | 6:9 | -3 | 6 |
| 7 |
|
Real Santa Cruz | 7 | 1 | 2 | 4 | 7:10 | -3 | 5 |
| 8 |
|
CD Guabirá | 7 | 0 | 2 | 5 | 5:14 | -9 | 2 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Bolívar | 7 | 5 | 1 | 1 | 20:2 | 18 | 16 |
| 2 |
|
Blooming | 7 | 5 | 1 | 1 | 13:11 | 2 | 16 |
| 3 |
|
Real Tomayapo | 7 | 3 | 3 | 1 | 7:9 | -2 | 12 |
| 4 |
|
Independiente Petrolero | 7 | 2 | 2 | 3 | 9:10 | -1 | 8 |
| 5 |
|
Always Ready | 7 | 2 | 2 | 3 | 5:8 | -3 | 8 |
| 6 |
|
Royal Pari | 7 | 2 | 2 | 3 | 8:13 | -5 | 8 |
| 7 |
|
Jorge Wilstermann | 7 | 2 | 1 | 4 | 4:6 | -2 | 7 |
| 8 |
|
Universitario de Vinto | 7 | 1 | 2 | 4 | 6:13 | -7 | 5 |
| Playoff | |
| Playoff |
