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| 30.04.2022 | 10:15 | MFK Chrudim | - | MFK Vyškov | 0:0 (0:0) | |
| 10:15 | FK Fotbal Třinec | - | 1. FK Příbram | 4:1 (1:0) | ||
| 10:15 | FK Dukla Praha | - | AC Sparta Praha B | 2:2 (0:1) | ||
| 17:00 | SK Líšeň | - | 1. SK Prostějov | 2:0 (1:0) | ||
| 17:00 | SFC Opava | - | FK Varnsdorf | 3:1 (0:0) | ||
| 01.05.2022 | 13:15 | FC Sellier & Bellot Vlašim | - | Zbrojovka Brno | 1:2 (1:1) | |
| 17:00 | FK MAS Táborsko | - | FK Ústí nad Labem | 3:0 (2:0) | ||
| 18:00 | Vysočina Jihlava | - | Viktoria Žižkov | 4:3 (2:2) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zbrojovka Brno | 27 | 21 | 2 | 4 | 56:24 | 32 | 65 |
| 2 |
|
SK Líšeň | 27 | 13 | 8 | 6 | 42:28 | 14 | 47 |
| 3 |
|
FC Sellier & Bellot Vlašim | 27 | 14 | 4 | 9 | 53:36 | 17 | 46 |
| 4 |
|
AC Sparta Praha B | 27 | 13 | 6 | 8 | 47:32 | 15 | 45 |
| 5 |
|
SFC Opava | 27 | 12 | 9 | 6 | 42:29 | 13 | 45 |
| 6 |
|
FK Varnsdorf | 27 | 11 | 5 | 11 | 41:35 | 6 | 38 |
| 7 |
|
Vysočina Jihlava | 27 | 10 | 8 | 9 | 26:31 | -5 | 38 |
| 8 |
|
FK Dukla Praha | 27 | 10 | 7 | 10 | 37:37 | 0 | 37 |
| 9 |
|
FK MAS Táborsko | 27 | 9 | 9 | 9 | 31:31 | 0 | 36 |
| 10 |
|
1. SK Prostějov | 27 | 10 | 3 | 14 | 27:43 | -16 | 33 |
| 11 |
|
1. FK Příbram | 27 | 8 | 8 | 11 | 33:44 | -11 | 32 |
| 12 |
|
MFK Vyškov | 27 | 8 | 7 | 12 | 40:41 | -1 | 31 |
| 13 |
|
MFK Chrudim | 27 | 7 | 10 | 10 | 24:32 | -8 | 31 |
| 14 |
|
FK Fotbal Třinec | 27 | 8 | 6 | 13 | 34:47 | -13 | 30 |
| 15 |
|
FK Ústí nad Labem | 27 | 5 | 10 | 12 | 23:42 | -19 | 25 |
| 16 |
|
Viktoria Žižkov | 27 | 2 | 8 | 17 | 25:49 | -24 | 14 |
| Ascenso | |
| Playoff | |
| Descenso |
