07.01.2022 16:00 Medeama SC - Berekum Chelsea 1:1 (0:1)
08.01.2022 16:00 Accra Lions - WAFA 0:0 (0:0)
16:00 Bibiani Gold Stars - Hearts of Oak 0:1 (0:1)
09.01.2022 16:00 Asante Kotoko - Ashanti Gold 3:1 (0:0)
16:00 Bechem United - Real Tamale United 2:0 (1:0)
16:00 Dreams FC - Legon Cities 0:1 (0:0)
16:00 Eleven Wonders - King Faisal 2:0 (0:0)
16:00 Elmina Sharks - Aduana Stars 0:1 (0:1)
16:00 Great Olympics - Karela FC 1:1 (0:0)
# Equipo P V E D Goles DG Pun.
1 Asante Kotoko, Ghana Asante Kotoko 12 8 3 1 19:7 12 27
2 Aduana Stars, Ghana Aduana Stars 12 7 2 3 18:11 7 23
3 King Faisal, Ghana King Faisal 12 7 2 3 15:10 5 23
4 Medeama SC, Ghana Medeama SC 12 6 4 2 9:7 2 22
5 Bechem United, Ghana Bechem United 12 6 3 3 15:7 8 21
6 Great Olympics, Ghana Great Olympics 12 4 6 2 13:8 5 18
7 Hearts of Oak, Ghana Hearts of Oak 12 4 6 2 10:7 3 18
8 Dreams FC, Ghana Dreams FC 12 4 4 4 23:22 1 16
9 Real Tamale United, Ghana Real Tamale United 12 4 3 5 15:17 -2 15
10 Accra Lions, Ghana Accra Lions 12 4 3 5 9:16 -7 15
11 Karela FC, Ghana Karela FC 12 3 5 4 16:17 -1 14
12 Legon Cities, Ghana Legon Cities 12 3 4 5 9:10 -1 13
13 Bibiani Gold Stars, Ghana Bibiani Gold Stars 12 4 1 7 12:14 -2 13
14 Berekum Chelsea, Ghana Berekum Chelsea 12 3 4 5 8:10 -2 13
15 Eleven Wonders, Ghana Eleven Wonders 12 3 3 6 10:14 -4 12
16 Ashanti Gold, Ghana Ashanti Gold 12 3 3 6 6:11 -5 12
17 WAFA, Ghana WAFA 12 3 3 6 7:13 -6 12
18 Elmina Sharks, Ghana Elmina Sharks 12 2 1 9 7:20 -13 7
  Champions League
  Descenso