04.06.2022 17:00 Accra Lions - Berekum Chelsea 2:0 (1:0)
05.06.2022 17:00 Bechem United - Aduana Stars 1:0 (1:0)
17:00 Bibiani Gold Stars - WAFA 3:4 (2:0)
17:00 Dreams FC - Ashanti Gold 1:0 (1:0)
17:00 Eleven Wonders - Legon Cities 0:0 (0:0)
17:00 Elmina Sharks - Medeama SC 1:3 (0:3)
17:00 Great Olympics - Asante Kotoko 0:1 (0:0)
17:00 Karela FC - Real Tamale United 5:1 (2:0)
20:00 King Faisal - Hearts of Oak 1:0 (0:0)
# Equipo P V E D Goles DG Pun.
1 Asante Kotoko, Ghana Asante Kotoko 32 18 9 5 44:19 25 63
2 Bechem United, Ghana Bechem United 32 13 14 5 35:21 14 53
3 Medeama SC, Ghana Medeama SC 32 15 8 9 26:22 4 53
4 Hearts of Oak, Ghana Hearts of Oak 32 12 12 8 32:22 10 48
5 Karela FC, Ghana Karela FC 32 12 12 8 42:33 9 48
6 Berekum Chelsea, Ghana Berekum Chelsea 32 12 10 10 28:28 0 46
7 Legon Cities, Ghana Legon Cities 32 11 12 9 33:24 9 45
8 Aduana Stars, Ghana Aduana Stars 32 11 12 9 32:25 7 45
9 Great Olympics, Ghana Great Olympics 32 11 11 10 31:29 2 44
10 Accra Lions, Ghana Accra Lions 32 12 8 12 24:35 -11 44
11 Ashanti Gold, Ghana Ashanti Gold 32 12 7 13 42:34 8 43
12 Bibiani Gold Stars, Ghana Bibiani Gold Stars 32 13 3 16 31:38 -7 42
13 King Faisal, Ghana King Faisal 32 11 6 15 28:32 -4 39
14 Dreams FC, Ghana Dreams FC 32 9 11 12 44:44 0 38
15 Eleven Wonders, Ghana Eleven Wonders 32 9 10 13 27:36 -9 37
16 Real Tamale United, Ghana Real Tamale United 32 8 11 13 35:47 -12 35
17 WAFA, Ghana WAFA 32 7 11 14 26:41 -15 32
18 Elmina Sharks, Ghana Elmina Sharks 32 5 7 20 22:52 -30 22
  Champions League
  Descenso