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| 19.03.2022 | 16:00 | Club Necaxa | - | Deportivo Toluca | 3:4 (2:1) | |
| 17:30 | Puebla FC | - | CF Pachuca | 0:3 (0:2) | ||
| 18:00 | UANL Tigres | - | Mazatlán FC | 5:0 (3:0) | ||
| 18:15 | Deportivo Guadalajara | - | Club Tijuana | 3:0 (0:0) | ||
| 18:30 | Gallos Blancos | - | Cruz Azul | 4:0 (3:0) | ||
| 18:30 | Santos Laguna | - | Atlético San Luis | 2:2 (0:1) | ||
| 18:30 | Pumas UNAM | - | CF América | 1:1 (0:1) | ||
| 18:30 | CF Monterrey | - | Atlas Guadalajara | 1:1 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 10 | 8 | 0 | 2 | 31:11 | 20 | 24 |
| 2 |
|
Pumas UNAM | 10 | 7 | 3 | 0 | 22:10 | 12 | 24 |
| 3 |
|
Deportivo Toluca | 10 | 5 | 2 | 3 | 18:16 | 2 | 17 |
| 4 |
|
Club Necaxa | 9 | 4 | 2 | 3 | 21:14 | 7 | 14 |
| 5 |
|
Gallos Blancos | 10 | 4 | 2 | 4 | 10:14 | -4 | 14 |
| 6 |
|
FC Juárez | 9 | 4 | 1 | 4 | 11:12 | -1 | 13 |
| 7 |
|
CF América | 10 | 2 | 2 | 6 | 12:16 | -4 | 8 |
| 8 |
|
Cruz Azul | 10 | 2 | 1 | 7 | 14:25 | -11 | 7 |
| 9 |
|
Puebla FC | 10 | 1 | 1 | 8 | 5:26 | -21 | 4 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 10 | 7 | 3 | 0 | 21:5 | 16 | 24 |
| 2 |
|
UANL Tigres | 10 | 7 | 1 | 2 | 21:12 | 9 | 22 |
| 3 |
|
Atlas Guadalajara | 10 | 6 | 2 | 2 | 27:13 | 14 | 20 |
| 4 |
|
Santos Laguna | 10 | 5 | 3 | 2 | 18:14 | 4 | 18 |
| 5 |
|
CF Monterrey | 10 | 4 | 3 | 3 | 19:11 | 8 | 15 |
| 6 |
|
Club Tijuana | 9 | 4 | 1 | 4 | 16:14 | 2 | 13 |
| 7 |
|
Club León | 9 | 1 | 3 | 5 | 9:19 | -10 | 6 |
| 8 |
|
Atlético San Luis | 10 | 1 | 1 | 8 | 4:26 | -22 | 4 |
| 9 |
|
Mazatlán FC | 10 | 0 | 1 | 9 | 7:28 | -21 | 1 |
| Playoff | |
| Playoff |
