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| 30.03.2022 | 20:00 | Pumas UNAM | - | Gallos Blancos | 2:1 (1:0) | |
| 05.04.2022 | 18:45 | Atlético San Luis | - | Club Tijuana | 0:3 (0:1) | |
| 06.04.2022 | 23:00 | Club León | - | Atlas Guadalajara | 1:0 (1:0) | |
| 09.04.2022 | 16:00 | CF Pachuca | - | Club Necaxa | 0:1 (0:1) | |
| 17:00 | Mazatlán FC | - | Deportivo Guadalajara | 1:2 (0:2) | ||
| 10.04.2022 | 18:30 | Deportivo Toluca | - | FC Juárez | 2:2 (1:0) | |
| 27.04.2022 | 19:30 | CF Monterrey | - | UANL Tigres | 2:4 (1:1) | |
| 23:00 | CF América | - | Cruz Azul | 6:1 (2:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 13 | 9 | 1 | 3 | 37:15 | 22 | 28 |
| 2 |
|
Pumas UNAM | 12 | 8 | 4 | 0 | 26:13 | 13 | 28 |
| 3 |
|
Deportivo Toluca | 13 | 6 | 4 | 3 | 24:19 | 5 | 22 |
| 4 |
|
Club Necaxa | 12 | 6 | 2 | 4 | 26:16 | 10 | 20 |
| 5 |
|
FC Juárez | 12 | 5 | 2 | 5 | 16:18 | -2 | 17 |
| 6 |
|
CF América | 12 | 4 | 2 | 6 | 20:18 | 2 | 14 |
| 7 |
|
Gallos Blancos | 13 | 4 | 2 | 7 | 11:22 | -11 | 14 |
| 8 |
|
Cruz Azul | 13 | 2 | 2 | 9 | 16:34 | -18 | 8 |
| 9 |
|
Puebla FC | 12 | 2 | 1 | 9 | 8:29 | -21 | 7 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 12 | 9 | 3 | 0 | 27:7 | 20 | 30 |
| 2 |
|
UANL Tigres | 13 | 9 | 1 | 3 | 28:17 | 11 | 28 |
| 3 |
|
Atlas Guadalajara | 12 | 7 | 2 | 3 | 28:14 | 14 | 23 |
| 4 |
|
CF Monterrey | 13 | 6 | 3 | 4 | 26:15 | 11 | 21 |
| 5 |
|
Santos Laguna | 12 | 6 | 3 | 3 | 21:18 | 3 | 21 |
| 6 |
|
Club Tijuana | 12 | 6 | 1 | 5 | 22:16 | 6 | 19 |
| 7 |
|
Club León | 12 | 3 | 3 | 6 | 14:23 | -9 | 12 |
| 8 |
|
Atlético San Luis | 13 | 1 | 1 | 11 | 4:34 | -30 | 4 |
| 9 |
|
Mazatlán FC | 13 | 0 | 1 | 12 | 10:36 | -26 | 1 |
| Playoff | |
| Playoff |
