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| 26.02.2022 | 16:00 | CF Pachuca | - | FC Juárez | 4:0 (1:0) | |
| 16:30 | Club Necaxa | - | Gallos Blancos | 3:1 (2:1) | ||
| 17:00 | Mazatlán FC | - | Santos Laguna | 0:3 (0:2) | ||
| 18:00 | UANL Tigres | - | Deportivo Guadalajara | 1:3 (0:1) | ||
| 18:30 | Atlas Guadalajara | - | Club León | 4:1 (3:0) | ||
| 18:30 | Cruz Azul | - | Puebla FC | 4:1 (2:0) | ||
| 19:45 | CF América | - | Deportivo Toluca | 1:2 (1:1) | ||
| 23:00 | CF Monterrey | - | Atlético San Luis | 7:0 (5:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 7 | 7 | 0 | 0 | 19:7 | 12 | 21 |
| 2 |
|
CF Pachuca | 7 | 5 | 0 | 2 | 20:7 | 13 | 15 |
| 3 |
|
Club Necaxa | 7 | 4 | 1 | 2 | 17:9 | 8 | 13 |
| 4 |
|
FC Juárez | 7 | 4 | 0 | 3 | 8:8 | 0 | 12 |
| 5 |
|
Deportivo Toluca | 7 | 3 | 2 | 2 | 10:8 | 2 | 11 |
| 6 |
|
Gallos Blancos | 8 | 2 | 2 | 4 | 5:14 | -9 | 8 |
| 7 |
|
CF América | 7 | 2 | 1 | 4 | 10:11 | -1 | 7 |
| 8 |
|
Cruz Azul | 7 | 1 | 1 | 5 | 9:16 | -7 | 4 |
| 9 |
|
Puebla FC | 7 | 0 | 1 | 6 | 1:19 | -18 | 1 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 7 | 5 | 2 | 0 | 14:3 | 11 | 17 |
| 2 |
|
Atlas Guadalajara | 7 | 5 | 0 | 2 | 21:10 | 11 | 15 |
| 3 |
|
UANL Tigres | 7 | 5 | 0 | 2 | 13:11 | 2 | 15 |
| 4 |
|
Santos Laguna | 7 | 4 | 2 | 1 | 14:8 | 6 | 14 |
| 5 |
|
Club Tijuana | 7 | 4 | 1 | 2 | 15:9 | 6 | 13 |
| 6 |
|
CF Monterrey | 8 | 3 | 2 | 3 | 15:9 | 6 | 11 |
| 7 |
|
Club León | 7 | 1 | 1 | 5 | 7:17 | -10 | 4 |
| 8 |
|
Atlético San Luis | 7 | 1 | 0 | 6 | 2:20 | -18 | 3 |
| 9 |
|
Mazatlán FC | 7 | 0 | 0 | 7 | 5:19 | -14 | 0 |
| Playoff | |
| Playoff |
