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| 05.03.2022 | 00:00 | Mineros de Fresnillo FC | - | Coras de Nayarit | 5:3 (2:2) | |
| 03:00 | Alacranes de Durango | - | Colima FC | 6:1 (3:1) | ||
| 18:00 | Cimarrones de Sonora II | - | Tecos Fútbol Club | 0:1 (0:0) | ||
| 22:30 | Tritones Vallarta | - | Gavilanes de Matamoros | 1:0 (1:0) | ||
| 23:00 | Saltillo FC | - | Mazorqueros | 1:5 (0:2) | ||
| 16.03.2022 | 18:00 | Correcaminos UAT II | - | Catedráticos Elite | 1:1 (1:1) | |
| 29.03.2022 | 22:30 | Tuzos de la UAZ | - | Leones Negros II | 2:3 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Tritones Vallarta | 8 | 7 | 1 | 0 | 19:7 | 12 | 27 |
| 2 |
|
Mazorqueros | 8 | 6 | 2 | 0 | 20:7 | 13 | 23 |
| 3 |
|
Alacranes de Durango | 8 | 4 | 3 | 1 | 20:6 | 14 | 18 |
| 4 |
|
Coras de Nayarit | 8 | 5 | 2 | 1 | 14:7 | 7 | 18 |
| 5 |
|
Saltillo FC | 8 | 4 | 1 | 3 | 12:13 | -1 | 14 |
| 6 |
|
Tecos Fútbol Club | 8 | 3 | 2 | 3 | 7:12 | -5 | 13 |
| 7 |
|
Tuzos de la UAZ | 8 | 2 | 3 | 3 | 13:12 | 1 | 11 |
| 8 |
|
Gavilanes de Matamoros | 8 | 1 | 5 | 2 | 7:8 | -1 | 10 |
| 9 |
|
Cimarrones de Sonora II | 8 | 2 | 2 | 4 | 8:10 | -2 | 10 |
| 10 |
|
Mineros de Fresnillo FC | 8 | 1 | 4 | 3 | 11:15 | -4 | 9 |
| 11 |
|
Colima FC | 8 | 2 | 2 | 4 | 7:13 | -6 | 9 |
| 12 |
|
Leones Negros II | 8 | 1 | 3 | 4 | 7:12 | -5 | 6 |
| 13 |
|
Correcaminos UAT II | 8 | 1 | 2 | 5 | 5:12 | -7 | 6 |
| 14 |
|
Catedráticos Elite | 8 | 0 | 2 | 6 | 5:21 | -16 | 2 |
| Playoff |
