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| I | Puebla FC | - | CF América | 1:1 (0:0) | ||
| V | CF América | - | Puebla FC | 3:2 (1:1) | ||
| I: 11.05.2022 04:05 | V: 15.05.2022 01:00 | Campeones: CF América | ||||
| I | Atlético San Luis | - | CF Pachuca | 2:2 (1:1) | ||
| V | CF Pachuca | - | Atlético San Luis | 3:2 (0:0) | ||
| I: 12.05.2022 02:00 | V: 15.05.2022 03:05 | Campeones: CF Pachuca | ||||
| I | Cruz Azul | - | UANL Tigres | 0:1 (0:1) | ||
| V | UANL Tigres | - | Cruz Azul | 0:1 (0:1) | ||
| I: 13.05.2022 02:00 | V: 16.05.2022 03:05 | |||||
| I | Deportivo Guadalajara | - | Atlas Guadalajara | 1:2 (0:2) | ||
| V | Atlas Guadalajara | - | Deportivo Guadalajara | 1:1 (1:0) | ||
| I: 13.05.2022 04:05 | V: 16.05.2022 01:00 | Campeones: Atlas Guadalajara | ||||
