 |
 |
|
|
| 29.10.2021 | 02:00 | Atlas Guadalajara | - | Club Tijuana | 0:2 (0:1) | |
| 30.10.2021 | 02:00 | Club Necaxa | - | Mazatlán FC | 2:1 (1:0) | |
| 04:00 | FC Juárez | - | Puebla FC | 0:2 (0:0) | ||
| 31.10.2021 | 00:00 | Gallos Blancos | - | Santos Laguna | 2:3 (0:2) | |
| 02:06 | CF Pachuca | - | Pumas UNAM | 1:1 (0:1) | ||
| 03:10 | UANL Tigres | - | Deportivo Guadalajara | 2:1 (1:0) | ||
| 19:00 | Deportivo Toluca | - | Club León | 0:0 (0:0) | ||
| 01.11.2021 | 00:05 | Cruz Azul | - | CF América | 2:1 (1:0) | |
| 02:05 | Atlético San Luis | - | CF Monterrey | 1:1 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 16 | 10 | 4 | 2 | 21:10 | 11 | 34 |
| 2 |
|
Atlas Guadalajara | 16 | 7 | 5 | 4 | 19:10 | 9 | 26 |
| 3 |
|
Club León | 16 | 7 | 5 | 4 | 17:14 | 3 | 26 |
| 4 |
|
UANL Tigres | 16 | 6 | 7 | 3 | 23:14 | 9 | 25 |
| 5 |
|
Deportivo Toluca | 16 | 6 | 6 | 4 | 22:21 | 1 | 24 |
| 6 |
|
Santos Laguna | 16 | 5 | 8 | 3 | 23:16 | 7 | 23 |
| 7 |
|
Cruz Azul | 16 | 5 | 8 | 3 | 18:13 | 5 | 23 |
| 8 |
|
CF Monterrey | 16 | 5 | 6 | 5 | 19:16 | 3 | 21 |
| 9 |
|
Puebla FC | 16 | 5 | 6 | 5 | 15:16 | -1 | 21 |
| 10 |
|
Club Necaxa | 16 | 6 | 2 | 8 | 16:19 | -3 | 20 |
| 11 |
|
Mazatlán FC | 16 | 5 | 5 | 6 | 18:23 | -5 | 20 |
| 12 |
|
Deportivo Guadalajara | 16 | 4 | 7 | 5 | 12:13 | -1 | 19 |
| 13 |
|
Atlético San Luis | 16 | 4 | 7 | 5 | 19:23 | -4 | 19 |
| 14 |
|
CF Pachuca | 16 | 4 | 6 | 6 | 17:18 | -1 | 18 |
| 15 |
|
Pumas UNAM | 16 | 4 | 6 | 6 | 13:20 | -7 | 18 |
| 16 |
|
FC Juárez | 16 | 4 | 4 | 8 | 14:22 | -8 | 16 |
| 17 |
|
Gallos Blancos | 16 | 3 | 6 | 7 | 11:17 | -6 | 15 |
| 18 |
|
Club Tijuana | 16 | 2 | 6 | 8 | 13:25 | -12 | 12 |
| Playoff | |
| Playoff |
