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| 30.04.2022 | 16:00 | UANL Tigres | - | Atlas Guadalajara | 2:2 (1:0) | |
| 16:00 | Deportivo Guadalajara | - | Santos Laguna | 3:0 (1:0) | ||
| 16:00 | Club León | - | CF Monterrey | 1:2 (1:2) | ||
| 17:00 | FC Juárez | - | Gallos Blancos | 2:0 (0:0) | ||
| 17:00 | Puebla FC | - | CF América | 1:2 (0:1) | ||
| 18:30 | CF Pachuca | - | Deportivo Toluca | 0:0 (0:0) | ||
| 19:00 | Club Tijuana | - | Mazatlán FC | 1:2 (1:2) | ||
| 22:30 | Club Necaxa | - | Pumas UNAM | 2:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 15 | 9 | 4 | 2 | 28:20 | 8 | 31 |
| 2 |
|
CF América | 15 | 9 | 1 | 5 | 22:16 | 6 | 28 |
| 3 |
|
Deportivo Toluca | 16 | 8 | 3 | 5 | 37:22 | 15 | 27 |
| 4 |
|
Cruz Azul | 15 | 8 | 2 | 5 | 32:22 | 10 | 26 |
| 5 |
|
Pumas UNAM | 15 | 8 | 2 | 5 | 24:14 | 10 | 26 |
| 6 |
|
CF Pachuca | 15 | 4 | 6 | 5 | 25:26 | -1 | 18 |
| 7 |
|
Puebla FC | 15 | 5 | 2 | 8 | 24:24 | 0 | 17 |
| 8 |
|
FC Juárez | 15 | 3 | 1 | 11 | 17:44 | -27 | 10 |
| 9 |
|
Gallos Blancos | 15 | 2 | 3 | 10 | 9:30 | -21 | 9 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 15 | 11 | 3 | 1 | 38:13 | 25 | 36 |
| 2 |
|
Atlas Guadalajara | 15 | 8 | 5 | 2 | 35:19 | 16 | 29 |
| 3 |
|
Santos Laguna | 15 | 8 | 2 | 5 | 25:17 | 8 | 26 |
| 4 |
|
UANL Tigres | 15 | 6 | 5 | 4 | 20:23 | -3 | 23 |
| 5 |
|
Club León | 15 | 6 | 2 | 7 | 19:23 | -4 | 20 |
| 6 |
|
CF Monterrey | 15 | 4 | 6 | 5 | 23:24 | -1 | 18 |
| 7 |
|
Mazatlán FC | 16 | 4 | 3 | 9 | 20:37 | -17 | 15 |
| 8 |
|
Club Tijuana | 15 | 4 | 1 | 10 | 12:24 | -12 | 13 |
| 9 |
|
Atlético San Luis | 15 | 2 | 3 | 10 | 15:27 | -12 | 9 |
| Playoff | |
| Playoff |
