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| 15.01.2022 | 16:00 | Club León | - | UANL Tigres | 0:1 (0:0) | |
| 16:00 | Cruz Azul | - | CF Pachuca | 4:2 (3:2) | ||
| 16:00 | Deportivo Toluca | - | Club Necaxa | 7:1 (4:1) | ||
| 16:00 | Atlas Guadalajara | - | Club Tijuana | 3:0 (2:0) | ||
| 16:00 | CF Monterrey | - | Deportivo Guadalajara | 2:2 (1:0) | ||
| 23:00 | CF América | - | Pumas UNAM | 1:0 (0:0) | ||
| 23:00 | Puebla FC | - | Gallos Blancos | 2:0 (0:0) | ||
| 16.01.2022 | 19:50 | Atlético San Luis | - | Mazatlán FC | 1:2 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 2 | 2 | 0 | 0 | 4:0 | 4 | 6 |
| 2 |
|
Cruz Azul | 2 | 2 | 0 | 0 | 6:3 | 3 | 6 |
| 3 |
|
Puebla FC | 2 | 1 | 1 | 0 | 4:2 | 2 | 4 |
| 4 |
|
Deportivo Toluca | 2 | 1 | 0 | 1 | 8:4 | 4 | 3 |
| 5 |
|
FC Juárez | 1 | 1 | 0 | 0 | 3:1 | 2 | 3 |
| 6 |
|
CF Pachuca | 2 | 0 | 1 | 1 | 4:6 | -2 | 1 |
| 7 |
|
Pumas UNAM | 2 | 0 | 0 | 2 | 1:3 | -2 | 0 |
| 8 |
|
Gallos Blancos | 2 | 0 | 0 | 2 | 0:5 | -5 | 0 |
| 9 |
|
Club Necaxa | 1 | 0 | 0 | 1 | 1:7 | -6 | 0 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlas Guadalajara | 2 | 2 | 0 | 0 | 4:0 | 4 | 6 |
| 2 |
|
UANL Tigres | 1 | 1 | 0 | 0 | 1:0 | 1 | 3 |
| 3 |
|
Mazatlán FC | 2 | 1 | 0 | 1 | 2:2 | 0 | 3 |
| 4 |
|
Deportivo Guadalajara | 2 | 0 | 2 | 0 | 3:3 | 0 | 2 |
| 5 |
|
CF Monterrey | 2 | 0 | 2 | 0 | 2:2 | 0 | 2 |
| 6 |
|
Santos Laguna | 1 | 0 | 1 | 0 | 0:0 | 0 | 1 |
| 7 |
|
Atlético San Luis | 2 | 0 | 1 | 1 | 2:3 | -1 | 1 |
|
Club León | 2 | 0 | 1 | 1 | 2:3 | -1 | 1 | |
| 9 |
|
Club Tijuana | 2 | 0 | 1 | 1 | 2:5 | -3 | 1 |
| Playoff | |
| Playoff |
