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| 26.02.2022 | 16:00 | Atlas Guadalajara | - | Club León | 5:0 (1:0) | |
| 16:00 | UANL Tigres | - | Deportivo Guadalajara | 1:4 (1:1) | ||
| 16:00 | Cruz Azul | - | Puebla FC | 1:2 (1:0) | ||
| 18:00 | CF Pachuca | - | FC Juárez | 4:2 (2:1) | ||
| 19:00 | Club Necaxa | - | Gallos Blancos | 2:0 (1:0) | ||
| 19:30 | Mazatlán FC | - | Santos Laguna | 2:0 (0:0) | ||
| 23:00 | CF América | - | Deportivo Toluca | 0:4 (0:2) | ||
| 23:00 | CF Monterrey | - | Atlético San Luis | 5:1 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cruz Azul | 7 | 5 | 0 | 2 | 16:8 | 8 | 15 |
| 2 |
|
CF América | 7 | 5 | 0 | 2 | 11:7 | 4 | 15 |
| 3 |
|
Deportivo Toluca | 7 | 4 | 1 | 2 | 18:11 | 7 | 13 |
| 4 |
|
Pumas UNAM | 7 | 4 | 0 | 3 | 10:5 | 5 | 12 |
| 5 |
|
Club Necaxa | 7 | 2 | 3 | 2 | 10:14 | -4 | 9 |
| 6 |
|
Puebla FC | 7 | 2 | 2 | 3 | 7:7 | 0 | 8 |
| 7 |
|
CF Pachuca | 7 | 2 | 2 | 3 | 15:18 | -3 | 8 |
| 8 |
|
FC Juárez | 7 | 2 | 1 | 4 | 9:13 | -4 | 7 |
| 9 |
|
Gallos Blancos | 8 | 1 | 1 | 6 | 5:18 | -13 | 4 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 7 | 5 | 2 | 0 | 18:6 | 12 | 17 |
| 2 |
|
Atlas Guadalajara | 7 | 4 | 2 | 1 | 16:8 | 8 | 14 |
| 3 |
|
UANL Tigres | 7 | 3 | 2 | 2 | 9:9 | 0 | 11 |
| 4 |
|
Club Tijuana | 7 | 3 | 1 | 3 | 7:10 | -3 | 10 |
| 5 |
|
Santos Laguna | 7 | 2 | 2 | 3 | 8:8 | 0 | 8 |
| 6 |
|
Mazatlán FC | 7 | 2 | 2 | 3 | 10:15 | -5 | 8 |
| 7 |
|
Club León | 7 | 2 | 2 | 3 | 6:11 | -5 | 8 |
| 8 |
|
CF Monterrey | 8 | 1 | 4 | 3 | 11:10 | 1 | 7 |
| 9 |
|
Atlético San Luis | 7 | 1 | 1 | 5 | 6:14 | -8 | 4 |
| Playoff | |
| Playoff |
