 |
 |
|
| 23.09.2021 | 16:00 | CF Pachuca | - | Club Necaxa | 5:1 (5:1) | |
| 24.09.2021 | 18:30 | Puebla FC | - | Cruz Azul | 2:1 (1:0) | |
| 19:30 | FC Juárez | - | Gallos Blancos | 0:0 (0:0) | ||
| 21:45 | Club Tijuana | - | Mazatlán FC | 1:2 (0:1) | ||
| 25.09.2021 | 16:00 | UANL Tigres | - | Pumas UNAM | 6:0 (2:0) | |
| 18:00 | CF América | - | Deportivo Guadalajara | 5:1 (3:0) | ||
| 18:30 | Atlas Guadalajara | - | Club León | 2:3 (2:0) | ||
| 26.09.2021 | 16:00 | Santos Laguna | - | CF Monterrey | 2:0 (1:0) | |
| 18:30 | Deportivo Toluca | - | Atlético San Luis | 1:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 10 | 8 | 1 | 1 | 23:9 | 14 | 25 |
| 2 |
|
Club Necaxa | 10 | 7 | 2 | 1 | 26:17 | 9 | 23 |
| 3 |
|
CF Pachuca | 10 | 5 | 3 | 2 | 23:11 | 12 | 18 |
| 4 |
|
UANL Tigres | 10 | 5 | 3 | 2 | 15:7 | 8 | 18 |
| 5 |
|
Mazatlán FC | 10 | 5 | 3 | 2 | 16:12 | 4 | 18 |
| 6 |
|
Club León | 10 | 5 | 3 | 2 | 15:14 | 1 | 18 |
| 7 |
|
Atlas Guadalajara | 10 | 5 | 2 | 3 | 17:12 | 5 | 17 |
| 8 |
|
Club Tijuana | 10 | 4 | 1 | 5 | 16:14 | 2 | 13 |
| 9 |
|
Cruz Azul | 10 | 3 | 4 | 3 | 10:18 | -8 | 13 |
| 10 |
|
FC Juárez | 10 | 3 | 3 | 4 | 17:14 | 3 | 12 |
| 11 |
|
Deportivo Toluca | 10 | 3 | 3 | 4 | 11:11 | 0 | 12 |
| 12 |
|
Atlético San Luis | 10 | 3 | 3 | 4 | 15:23 | -8 | 12 |
| 13 |
|
Deportivo Guadalajara | 10 | 2 | 4 | 4 | 17:19 | -2 | 10 |
| 14 |
|
Gallos Blancos | 10 | 2 | 4 | 4 | 7:9 | -2 | 10 |
| 15 |
|
Santos Laguna | 10 | 2 | 3 | 5 | 13:16 | -3 | 9 |
| 16 |
|
Pumas UNAM | 10 | 1 | 4 | 5 | 10:22 | -12 | 7 |
| 17 |
|
Puebla FC | 10 | 1 | 2 | 7 | 13:26 | -13 | 5 |
| 18 |
|
CF Monterrey | 10 | 0 | 4 | 6 | 6:16 | -10 | 4 |
| Playoff |
