 |
 |
|
| 14.10.2021 | 18:30 | Gallos Blancos | - | Club Tijuana | 2:0 (0:0) | |
| 15.10.2021 | 18:15 | Club Necaxa | - | Puebla FC | 4:3 (1:1) | |
| 19:15 | Mazatlán FC | - | Atlas Guadalajara | 1:1 (0:0) | ||
| 16.10.2021 | 16:30 | CF Pachuca | - | Santos Laguna | 0:1 (0:1) | |
| 18:30 | Cruz Azul | - | UANL Tigres | 0:1 (0:1) | ||
| 18:30 | CF Monterrey | - | Club León | 0:1 (0:0) | ||
| 18:45 | Atlético San Luis | - | CF América | 1:1 (0:0) | ||
| 17.10.2021 | 18:15 | Deportivo Guadalajara | - | Deportivo Toluca | 2:2 (1:1) | |
| 18:30 | Pumas UNAM | - | FC Juárez | 2:0 (1:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Necaxa | 13 | 9 | 3 | 1 | 35:21 | 14 | 30 |
| 2 |
|
CF América | 13 | 9 | 2 | 2 | 26:14 | 12 | 29 |
| 3 |
|
Club León | 13 | 8 | 3 | 2 | 23:19 | 4 | 27 |
| 4 |
|
UANL Tigres | 13 | 7 | 4 | 2 | 22:8 | 14 | 25 |
| 5 |
|
CF Pachuca | 13 | 7 | 3 | 3 | 29:13 | 16 | 24 |
| 6 |
|
Mazatlán FC | 13 | 6 | 4 | 3 | 20:18 | 2 | 22 |
| 7 |
|
Atlas Guadalajara | 13 | 5 | 4 | 4 | 20:18 | 2 | 19 |
| 8 |
|
Santos Laguna | 13 | 5 | 3 | 5 | 18:16 | 2 | 18 |
| 9 |
|
Gallos Blancos | 13 | 4 | 5 | 4 | 11:10 | 1 | 17 |
| 10 |
|
Deportivo Toluca | 13 | 4 | 4 | 5 | 16:16 | 0 | 16 |
| 11 |
|
Club Tijuana | 13 | 5 | 1 | 7 | 19:22 | -3 | 16 |
| 12 |
|
FC Juárez | 13 | 4 | 3 | 6 | 22:19 | 3 | 15 |
| 13 |
|
Deportivo Guadalajara | 13 | 3 | 6 | 4 | 23:22 | 1 | 15 |
| 14 |
|
Cruz Azul | 13 | 3 | 4 | 6 | 14:25 | -11 | 13 |
| 15 |
|
Atlético San Luis | 13 | 3 | 4 | 6 | 19:33 | -14 | 13 |
| 16 |
|
Pumas UNAM | 13 | 2 | 4 | 7 | 12:24 | -12 | 10 |
| 17 |
|
Puebla FC | 13 | 1 | 3 | 9 | 18:34 | -16 | 6 |
| 18 |
|
CF Monterrey | 13 | 0 | 4 | 9 | 8:23 | -15 | 4 |
| Playoff |
