 |
 |
|
|
| 17.03.2022 | 18:30 | Gallos Blancos | - | Atlético San Luis | 1:0 (0:0) | |
| 18.03.2022 | 18:15 | Puebla FC | - | Santos Laguna | 2:2 (0:0) | |
| 19:30 | Mazatlán FC | - | Club León | 1:1 (1:1) | ||
| 21:45 | Club Tijuana | - | FC Juárez | 3:2 (2:1) | ||
| 19.03.2022 | 16:00 | CF Pachuca | - | Cruz Azul | 3:2 (1:0) | |
| 18:00 | UANL Tigres | - | CF Monterrey | 0:4 (0:1) | ||
| 18:30 | Pumas UNAM | - | Club Necaxa | 0:0 (0:0) | ||
| 20.03.2022 | 18:00 | CF América | - | Deportivo Toluca | 3:2 (2:1) | |
| 18:30 | Atlas Guadalajara | - | Deportivo Guadalajara | 0:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 11 | 8 | 2 | 1 | 24:11 | 13 | 36 |
| 2 |
|
Atlas Guadalajara | 11 | 7 | 4 | 0 | 18:7 | 11 | 36 |
| 3 |
|
Club León | 11 | 7 | 2 | 2 | 15:9 | 6 | 30 |
| 4 |
|
Deportivo Guadalajara | 11 | 6 | 3 | 2 | 21:12 | 9 | 29 |
| 5 |
|
Club Tijuana | 11 | 5 | 3 | 3 | 20:19 | 1 | 29 |
| 6 |
|
CF Monterrey | 11 | 5 | 2 | 4 | 22:21 | 1 | 28 |
| 7 |
|
Santos Laguna | 11 | 4 | 5 | 2 | 21:12 | 9 | 26 |
| 8 |
|
CF Pachuca | 11 | 6 | 0 | 5 | 20:16 | 4 | 25 |
| 9 |
|
Deportivo Toluca | 11 | 4 | 4 | 3 | 16:13 | 3 | 24 |
| 10 |
|
Pumas UNAM | 11 | 4 | 3 | 4 | 12:12 | 0 | 22 |
| 11 |
|
Cruz Azul | 11 | 4 | 1 | 6 | 12:15 | -3 | 22 |
| 12 |
|
Mazatlán FC | 11 | 2 | 4 | 5 | 11:21 | -10 | 20 |
| 13 |
|
UANL Tigres | 11 | 3 | 2 | 6 | 13:25 | -12 | 20 |
| 14 |
|
Atlético San Luis | 11 | 4 | 1 | 6 | 14:16 | -2 | 19 |
| 15 |
|
Club Necaxa | 11 | 3 | 1 | 7 | 13:19 | -6 | 17 |
| 16 |
|
Gallos Blancos | 11 | 3 | 0 | 8 | 7:15 | -8 | 16 |
| 17 |
|
FC Juárez | 11 | 1 | 4 | 6 | 13:19 | -6 | 14 |
| 18 |
|
Puebla FC | 11 | 0 | 5 | 6 | 6:16 | -10 | 14 |
| Playoff |
