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| 23.10.2021 | 02:00 | San Francisco FC | - | Atlético Chiriquí | 1:0 (0:0) | |
| 23:00 | Árabe Unido | - | Deportivo del Este | 1:1 (1:0) | ||
| 23:00 | Alianza | - | Sporting San Miguelito | 1:0 (0:0) | ||
| 24.10.2021 | 01:00 | Veraguas Club Deportivo | - | UD Universitario | 1:0 (0:0) | |
| 01:00 | Plaza Amador | - | Tauro FC | 1:2 (1:0) | ||
| 03:00 | Herrera FC | - | Independiente de La Chorrera | 2:1 (2:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Tauro FC | 12 | 7 | 3 | 2 | 15:7 | 8 | 24 |
| 2 |
|
Alianza | 12 | 6 | 4 | 2 | 11:7 | 4 | 22 |
| 3 |
|
Plaza Amador | 12 | 4 | 5 | 3 | 13:7 | 6 | 17 |
| 4 |
|
Deportivo del Este | 12 | 3 | 8 | 1 | 13:9 | 4 | 17 |
| 5 |
|
Árabe Unido | 12 | 3 | 5 | 4 | 7:8 | -1 | 14 |
| 6 |
|
Sporting San Miguelito | 12 | 3 | 5 | 4 | 8:12 | -4 | 14 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Independiente de La Chorrera | 12 | 5 | 3 | 4 | 14:13 | 1 | 18 |
| 2 |
|
Herrera FC | 12 | 3 | 7 | 2 | 15:13 | 2 | 16 |
| 3 |
|
Veraguas Club Deportivo | 12 | 4 | 3 | 5 | 9:12 | -3 | 15 |
| 4 |
|
UD Universitario | 12 | 4 | 1 | 7 | 10:16 | -6 | 13 |
| 5 |
|
Atlético Chiriquí | 12 | 2 | 4 | 6 | 8:12 | -4 | 10 |
| 6 |
|
San Francisco FC | 12 | 2 | 4 | 6 | 7:14 | -7 | 10 |
| Playoff | |
| Playoff | |
| Playoff | |
| Playoff |
