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| 06.11.2021 | 21:00 | UD Universitario | - | Atlético Chiriquí | 4:1 (1:0) | |
| 22:00 | Árabe Unido | - | Alianza | 1:0 (0:0) | ||
| 23:00 | San Francisco FC | - | Independiente de La Chorrera | 1:1 (0:1) | ||
| 07.11.2021 | 00:00 | Herrera FC | - | Veraguas Club Deportivo | 1:1 (1:1) | |
| 22:00 | Tauro FC | - | Sporting San Miguelito | 1:0 (0:0) | ||
| 23:00 | Plaza Amador | - | Deportivo del Este | 0:0 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| 1 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Tauro FC | 14 | 8 | 4 | 2 | 17:8 | 9 | 28 |
| 2 |
|
Alianza | 14 | 7 | 4 | 3 | 12:8 | 4 | 25 |
| 3 |
|
Plaza Amador | 14 | 4 | 7 | 3 | 14:8 | 6 | 19 |
| 4 |
|
Deportivo del Este | 14 | 3 | 9 | 2 | 13:10 | 3 | 18 |
| 5 |
|
Árabe Unido | 14 | 4 | 6 | 4 | 9:9 | 0 | 18 |
| 6 |
|
Sporting San Miguelito | 14 | 3 | 6 | 5 | 9:14 | -5 | 15 |
| 2 | |||||||||
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Independiente de La Chorrera | 14 | 6 | 4 | 4 | 18:15 | 3 | 22 |
| 2 |
|
Herrera FC | 14 | 3 | 9 | 2 | 16:14 | 2 | 18 |
| 3 |
|
UD Universitario | 14 | 5 | 1 | 8 | 14:18 | -4 | 16 |
| 4 |
|
Veraguas Club Deportivo | 14 | 4 | 4 | 6 | 11:16 | -5 | 16 |
| 5 |
|
San Francisco FC | 14 | 3 | 5 | 6 | 9:15 | -6 | 14 |
| 6 |
|
Atlético Chiriquí | 14 | 2 | 5 | 7 | 9:16 | -7 | 11 |
| Playoff | |
| Playoff | |
| Playoff | |
| Playoff |
