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| I | Luis Ángel Firpo | - | Isidro Metapán | 1:0 (0:0) | ||
| V | Isidro Metapán | - | Luis Ángel Firpo | 1:3 (1:1) | ||
| I: 05.05.2021 22:30 | V: 09.05.2021 03:15 | Campeones: Luis Ángel Firpo | ||||
| I | CD Águila | - | Alianza | 0:1 (0:0) | ||
| V | Alianza | - | CD Águila | 2:1 (0:1) | ||
| I: 05.05.2021 23:00 | V: 09.05.2021 23:15 | Campeones: Alianza | ||||
| I | FAS | - | Municipal Limeño | 2:1 (1:0) | ||
| V | Municipal Limeño | - | FAS | 2:4 (0:0, 2:1) pn. | ||
| I: 05.05.2021 23:30 | V: 09.05.2021 23:00 | Campeones: FAS | ||||
| I | Santa Tecla FC | - | Once Municipal | 1:1 (0:0) | ||
| V | Once Municipal | - | Santa Tecla FC | 1:2 (0:0) | ||
| I: 06.05.2021 03:00 | V: 09.05.2021 23:00 | Campeones: Santa Tecla FC | ||||
