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| 19.02.2022 | 11:00 | Afjet Afyonspor | - | Niğde Anadolu FK | 3:1 (1:1) | |
| 11:00 | Bayburt İl Özel İdare | - | Sarıyer SK | 0:2 (0:0) | ||
| 11:00 | Diyarbekirspor | - | Inegölspor | 0:2 (0:1) | ||
| 11:00 | Ergene Velimeşe | - | 1461 Trabzon FK | 0:3 (0:2) | ||
| 11:00 | Etimesgut Belediyespor | - | Adıyamanspor | 3:1 (0:0) | ||
| 11:00 | Kahramanmaraşspor | - | Bodrumspor | 1:3 (0:2) | ||
| 11:00 | Sakaryaspor | - | Ankaraspor | 1:0 (1:0) | ||
| 11:00 | Serik Belediyespor | - | Vanspor FK | 1:2 (0:2) | ||
| 11:00 | Sivas Belediyespor | - | Çorum FK | 2:0 (1:0) | ||
| 11:00 | Turgutluspor | - | Somaspor | 1:1 (0:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 26 | 17 | 7 | 2 | 52:16 | 36 | 58 |
| 2 |
|
1461 Trabzon FK | 26 | 17 | 7 | 2 | 46:18 | 28 | 58 |
| 3 |
|
Sivas Belediyespor | 26 | 14 | 7 | 5 | 47:21 | 26 | 49 |
| 4 |
|
Vanspor FK | 26 | 14 | 6 | 6 | 38:32 | 6 | 48 |
| 5 |
|
Bodrumspor | 26 | 14 | 5 | 7 | 40:22 | 18 | 47 |
| 6 |
|
Afjet Afyonspor | 26 | 12 | 8 | 6 | 49:30 | 19 | 44 |
| 7 |
|
Bayburt İl Özel İdare | 26 | 13 | 5 | 8 | 36:26 | 10 | 44 |
| 8 |
|
Çorum FK | 26 | 12 | 7 | 7 | 38:24 | 14 | 43 |
| 9 |
|
Somaspor | 26 | 12 | 6 | 8 | 41:35 | 6 | 42 |
| 10 |
|
Ankaraspor | 26 | 10 | 8 | 8 | 41:29 | 12 | 38 |
| 11 |
|
Inegölspor | 26 | 11 | 4 | 11 | 33:36 | -3 | 37 |
| 12 |
|
Etimesgut Belediyespor | 26 | 8 | 8 | 10 | 31:37 | -6 | 32 |
| 13 |
|
Serik Belediyespor | 26 | 9 | 4 | 13 | 31:36 | -5 | 31 |
| 14 |
|
Sarıyer SK | 26 | 8 | 5 | 13 | 30:37 | -7 | 29 |
| 15 |
|
Diyarbekirspor | 26 | 8 | 4 | 14 | 26:31 | -5 | 28 |
| 16 |
|
Adıyamanspor | 26 | 9 | 1 | 16 | 36:48 | -12 | 28 |
| 17 |
|
Turgutluspor | 26 | 5 | 9 | 12 | 22:43 | -21 | 24 |
| 18 |
|
Ergene Velimeşe | 26 | 6 | 3 | 17 | 27:54 | -27 | 21 |
| 19 |
|
Kahramanmaraşspor | 26 | 3 | 5 | 18 | 19:62 | -43 | 14 |
| 20 |
|
Niğde Anadolu FK | 26 | 1 | 5 | 20 | 19:65 | -46 | 8 |
| Ascenso | |
| Playoff | |
| Descenso |
