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| 20.03.2022 | 12:00 | Çorum FK | - | Bodrumspor | 1:1 (0:0) | |
| 12:00 | Ergene Velimeşe | - | Afjet Afyonspor | 2:1 (0:0) | ||
| 12:00 | Etimesgut Belediyespor | - | Diyarbekirspor | 0:1 (0:0) | ||
| 12:00 | Kahramanmaraşspor | - | 1461 Trabzon FK | 1:3 (0:1) | ||
| 12:00 | Sakaryaspor | - | Adıyamanspor | 2:0 (0:0) | ||
| 12:00 | Sarıyer SK | - | Vanspor FK | 1:1 (1:0) | ||
| 12:00 | Serik Belediyespor | - | Inegölspor | 1:1 (0:0) | ||
| 12:00 | Sivas Belediyespor | - | Ankaraspor | 2:0 (0:0) | ||
| 12:00 | Turgutluspor | - | Niğde Anadolu FK | 1:3 (0:2) | ||
| 13.04.2022 | 13:00 | Bayburt İl Özel İdare | - | Somaspor | 0:1 (0:0) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 30 | 20 | 8 | 2 | 60:20 | 40 | 68 |
| 2 |
|
1461 Trabzon FK | 30 | 19 | 7 | 4 | 54:22 | 32 | 64 |
| 3 |
|
Bodrumspor | 30 | 17 | 6 | 7 | 47:23 | 24 | 57 |
| 4 |
|
Vanspor FK | 30 | 15 | 9 | 6 | 43:36 | 7 | 54 |
| 5 |
|
Sivas Belediyespor | 30 | 15 | 8 | 7 | 52:26 | 26 | 53 |
| 6 |
|
Somaspor | 30 | 15 | 6 | 9 | 46:38 | 8 | 51 |
| 7 |
|
Afjet Afyonspor | 30 | 14 | 8 | 8 | 57:34 | 23 | 50 |
| 8 |
|
Çorum FK | 30 | 13 | 9 | 8 | 43:28 | 15 | 48 |
| 9 |
|
Bayburt İl Özel İdare | 30 | 14 | 6 | 10 | 38:30 | 8 | 48 |
| 10 |
|
Inegölspor | 30 | 13 | 6 | 11 | 40:39 | 1 | 45 |
| 11 |
|
Ankaraspor | 30 | 11 | 10 | 9 | 45:34 | 11 | 43 |
| 12 |
|
Etimesgut Belediyespor | 30 | 9 | 9 | 12 | 36:43 | -7 | 36 |
| 13 |
|
Serik Belediyespor | 30 | 9 | 6 | 15 | 36:46 | -10 | 33 |
| 14 |
|
Diyarbekirspor | 30 | 9 | 5 | 16 | 28:35 | -7 | 32 |
| 15 |
|
Sarıyer SK | 30 | 8 | 8 | 14 | 34:44 | -10 | 32 |
| 16 |
|
Adıyamanspor | 30 | 9 | 2 | 19 | 36:56 | -20 | 29 |
| 17 |
|
Turgutluspor | 30 | 6 | 10 | 14 | 25:50 | -25 | 28 |
| 18 |
|
Ergene Velimeşe | 30 | 8 | 3 | 19 | 31:59 | -28 | 27 |
| 19 |
|
Niğde Anadolu FK | 30 | 4 | 5 | 21 | 29:71 | -42 | 17 |
| 20 |
|
Kahramanmaraşspor | 30 | 4 | 5 | 21 | 21:67 | -46 | 17 |
| Ascenso | |
| Playoff | |
| Descenso |
