| 6. Jornada | 18.09.2021 | Jeunesse Esch | - | RFCU Luxemburg | 0:2 | ||||
| 7. Jornada | 22.09.2021 | RFCU Luxemburg | - | US Hostert | 7:0 | ||||
| 8. Jornada | 26.09.2021 | Progrès Niedercorn | - | RFCU Luxemburg | 0:2 | ||||
| 9. Jornada | 17.10.2021 | Union Titus Pétange | - | RFCU Luxemburg | 4:2 |  |
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| 10. Jornada | 23.10.2021 | RFCU Luxemburg | - | US Mondorf | 2:1 | ||||
| 11. Jornada | 07.11.2021 | Etzella Ettelbruck | - | RFCU Luxemburg | 1:2 | ||||
| 13. Jornada | 28.11.2021 | Victoria Rosport | - | RFCU Luxemburg | 3:1 |  |
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| 18. Jornada | 20.02.2022 | RFCU Luxemburg | - | FC Wiltz 71 | 1:3 | ||||
| 19. Jornada | 26.02.2022 | F91 Dudelange | - | RFCU Luxemburg | 1:1 | |
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| 23. Jornada | 02.04.2022 | RFCU Luxemburg | - | Union Titus Pétange | 0:0 | ||||
| 24. Jornada | 10.04.2022 | US Mondorf | - | RFCU Luxemburg | 2:3 | |
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| 25. Jornada | 16.04.2022 | RFCU Luxemburg | - | Etzella Ettelbruck | 1:2 | ||||
| 26. Jornada | 24.04.2022 | FC Differdange 03 | - | RFCU Luxemburg | 4:0 | |
Francia