| 1. Jornada | 28.08.2021 | FC Groningen [Sub 21] | - | NEC Nijmegen [Sub 21] | 2:1 | ||||
| 2. Jornada | 11.09.2021 | Almere City FC [Sub 21] | - | FC Groningen [Sub 21] | 1:2 | ||||
| 3. Jornada | 18.09.2021 | FC Groningen [Sub 21] | - | Feyenoord [Sub 21] | 2:1 | ||||
| 4. Jornada | 25.09.2021 | sc Heerenveen [Sub 21] | - | FC Groningen [Sub 21] | 4:2 | ||||
| 7. Jornada | 23.10.2021 | FC Groningen [Sub 21] | - | ADO Den Haag [Sub 21] | 2:1 | ||||
| 8. Jornada | 30.10.2021 | NAC Breda [Sub 21] | - | FC Groningen [Sub 21] | 0:2 | ||||
| 10. Jornada | 20.11.2021 | ADO Den Haag [Sub 21] | - | FC Groningen [Sub 21] | 4:2 | ||||
| 11. Jornada | 27.11.2021 | FC Groningen [Sub 21] | - | Almere City FC [Sub 21] | 3:0 | ||||
| 9. Jornada | 30.11.2021 | FC Groningen [Sub 21] | - | sc Heerenveen [Sub 21] | 3:2 | ||||
| 12. Jornada | 12.02.2022 | NEC Nijmegen [Sub 21] | - | FC Groningen [Sub 21] | 1:1 | ||||
| 13. Jornada | 26.02.2022 | Feyenoord [Sub 21] | - | FC Groningen [Sub 21] | 1:0 |
Países Bajos