| Octavos de final | 01.12.2021 | Panathinaikos | - | Volos NFC | 2:1 | ||||
| Octavos de final | 23.12.2021 | Volos NFC | - | Panathinaikos | 0:0 | ||||
| Cuartos de final | 19.01.2022 | Panathinaikos | - | Anagennisi Karditsa | 4:0 |  |
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| Cuartos de final | 09.02.2022 | Anagennisi Karditsa | - | Panathinaikos | 0:1 | ||||
| Semifinales | 20.04.2022 | Panathinaikos | - | Lamia | 1:0 | ||||
| Semifinales | 27.04.2022 | Lamia | - | Panathinaikos | 0:2 | ||||
| Final | 21.05.2022 | Panathinaikos | - | PAOK Saloniki | 1:0 | |
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