| 2. Jornada | 01.08.2021 | FK Chayka | - | FK SKA Rostov | 0:1 | ||||
| 3. Jornada | 08.08.2021 | FK SKA Rostov | - | Anzhi Makhachkala | 0:1 | ||||
| 8. Jornada | 08.09.2021 | FK Dinamo Makhachkala | - | FK SKA Rostov | 0:1 | ||||
| 9. Jornada | 12.09.2021 | FK SKA Rostov | - | Rotor-2 Volgograd | 1:0 | ||||
| 10. Jornada | 20.09.2021 | FK Tuapse | - | FK SKA Rostov | 0:3 |  |
 |
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| 12. Jornada | 03.10.2021 | FK SKA Rostov | - | Dinamo Stavropol | 2:1 | |
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| 13. Jornada | 10.10.2021 | Chernomorets Novorossisk | - | FK SKA Rostov | 0:1 | ||||
| 15. Jornada | 23.10.2021 | FK Biolog Novokubansk | - | FK SKA Rostov | 1:3 | ||||
| 20. Jornada | 06.03.2022 | FK SKA Rostov | - | FK Druzhba | 1:0 | |
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| 21. Jornada | 13.03.2022 | Alania-2 Vladikavkaz | - | FK SKA Rostov | 0:4 | ||||
| 22. Jornada | 20.03.2022 | FK SKA Rostov | - | Kuban-Holding Pavlovskaya | 0:1 | ||||
| 24. Jornada | 03.04.2022 | FK SKA Rostov | - | FK Dinamo Makhachkala | 0:1 | ||||
| 25. Jornada | 11.04.2022 | Rotor-2 Volgograd | - | FK SKA Rostov | 0:7 | ||||
| 32. Jornada | 22.05.2022 | FK Legion Dynamo Makhachkala | - | FK SKA Rostov | 1:1 | ||||
| 33. Jornada | 29.05.2022 | FK SKA Rostov | - | FK Mashuk KMV | 6:3 | |
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| 34. Jornada | 05.06.2022 | Spartak Nalchik | - | FK SKA Rostov | 1:2 | |
Rusia