| 5. Jornada | 03.10.2021 | Olympiacos | - | Panathinaikos | 0:0 |  |
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| 6. Jornada | 16.10.2021 | Panathinaikos | - | Ionikos Nikea | 4:1 | ||||
| 7. Jornada | 23.10.2021 | Asteras Tripolis | - | Panathinaikos | 2:1 | ||||
| 8. Jornada | 31.10.2021 | Panathinaikos | - | OFI Heraklion | 0:0 | ||||
| 9. Jornada | 07.11.2021 | Panathinaikos | - | PAOK Saloniki | 1:3 | ||||
| 10. Jornada | 22.11.2021 | Lamia | - | Panathinaikos | 1:3 | ||||
| 11. Jornada | 28.11.2021 | Panathinaikos | - | Panetolikos | 2:0 | ||||
| 12. Jornada | 05.12.2021 | AEK Athen | - | Panathinaikos | 1:0 | ||||
| 13. Jornada | 11.12.2021 | Panathinaikos | - | Atromitos | 2:0 | ||||
| 15. Jornada | 19.12.2021 | Panathinaikos | - | PAS Giannina | 2:0 | ||||
| 16. Jornada | 05.01.2022 | Panathinaikos | - | Aris Saloniki | 2:0 | ||||
| 17. Jornada | 09.01.2022 | Volos NFC | - | Panathinaikos | 3:1 | ||||
| 18. Jornada | 16.01.2022 | Panathinaikos | - | Olympiacos | 0:0 | ||||
| 19. Jornada | 22.01.2022 | Ionikos Nikea | - | Panathinaikos | 0:1 | ||||
| 20. Jornada | 29.01.2022 | Panathinaikos | - | Asteras Tripolis | 0:1 | ||||
| 21. Jornada | 02.02.2022 | OFI Heraklion | - | Panathinaikos | 3:2 | ||||
| 22. Jornada | 06.02.2022 | PAOK Saloniki | - | Panathinaikos | 2:1 | |
Italia