| 1. Jornada | 17.07.2021 | Sportivo Luqueño | - | Cerro Porteño | 0:0 | ||||
| 2. Jornada | 26.07.2021 | Cerro Porteño | - | Libertad | 1:1 |  |
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| 3. Jornada | 31.07.2021 | River Plate | - | Cerro Porteño | 0:0 | ||||
| 4. Jornada | 08.08.2021 | Cerro Porteño | - | Guaireña FC | 2:0 | ||||
| 5. Jornada | 15.08.2021 | Club Olimpia | - | Cerro Porteño | 0:3 | |
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| 6. Jornada | 22.08.2021 | Sol de América | - | Cerro Porteño | 1:2 | ||||
| 7. Jornada | 29.08.2021 | Cerro Porteño | - | Club Nacional | 0:2 | ||||
| 12. Jornada | 19.10.2021 | Cerro Porteño | - | River Plate | 2:0 | ||||
| 13. Jornada | 25.10.2021 | Guaireña FC | - | Cerro Porteño | 0:2 | ||||
| 14. Jornada | 31.10.2021 | Cerro Porteño | - | Club Olimpia | 1:0 | ||||
| 15. Jornada | 08.11.2021 | Cerro Porteño | - | Sol de América | 3:0 | ||||
| 16. Jornada | 22.11.2021 | Club Nacional | - | Cerro Porteño | 1:5 | ||||
| 18. Jornada | 05.12.2021 | Guaraní | - | Cerro Porteño | 2:2 |  |
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Paraguay