| 1. Jornada | 18.10.2020 | River Plate | - | 12 de Octubre de Itauguá | 1:2 |  |
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| 2. Jornada | 24.10.2020 | Sportivo Luqueño | - | River Plate | 2:0 | ||||
| 3. Jornada | 01.11.2020 | River Plate | - | Guaraní | 1:0 | ||||
| 4. Jornada | 08.11.2020 | Libertad | - | River Plate | 3:1 | ||||
| 5. Jornada | 11.11.2020 | River Plate | - | Guaireña FC | 1:2 | |
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| 6. Jornada | 15.11.2020 | Sol de América | - | River Plate | 2:3 | ||||
| 7. Jornada | 20.11.2020 | River Plate | - | Cerro Porteño | 1:2 | |
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| 8. Jornada | 28.11.2020 | Club Olimpia | - | River Plate | 3:1 | ||||
| 9. Jornada | 05.12.2020 | General Díaz | - | River Plate | 0:0 |
Paraguay