| 4. Jornada | 16.07.2022 | Deportivo Guadalajara [] | - | Club León [] | 2:1 |  |
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| 6. Jornada | 31.07.2022 | Club Tijuana [] | - | Deportivo Guadalajara [] | 3:1 | ||||
| 7. Jornada | 06.08.2022 | Deportivo Guadalajara [] | - | CF Monterrey [] | 0:1 | ||||
| 8. Jornada | 13.08.2022 | Atlético San Luis [] | - | Deportivo Guadalajara [] | 2:1 | ||||
| 9. Jornada | 20.08.2022 | Deportivo Guadalajara [] | - | Mazatlán FC [] | 4:1 | ||||
| 11. Jornada | 03.09.2022 | Mazatlán FC [] | - | Deportivo Guadalajara [] | 2:8 | ||||
| 12. Jornada | 11.09.2022 | Deportivo Guadalajara [] | - | Atlético San Luis [] | 3:1 |
México