| 1. Jornada | 20.07.2021 | Zvezda Perm | - | FK Novosibirsk | 1:1 | ||||
| 2. Jornada | 24.07.2021 | FK Tyumen | - | FK Novosibirsk | 0:3 | ||||
| 3. Jornada | 01.08.2021 | FK Novosibirsk | - | FK Ural 2 | 1:3 | ||||
| 4. Jornada | 07.08.2021 | FK Novosibirsk | - | FK Chelyabinsk | 1:2 | ||||
| 5. Jornada | 18.08.2021 | Spartak Tuymazy | - | FK Novosibirsk | 0:1 | ||||
| 6. Jornada | 21.08.2021 | Torpedo Miass | - | FK Novosibirsk | 1:1 | ||||
| 7. Jornada | 29.08.2021 | FK Novosibirsk | - | Lada Tolyatti | 2:0 |  |
|||
| 8. Jornada | 05.09.2021 | FK Novosibirsk | - | Volga Ulyanovsk | 1:0 | ||||
| 9. Jornada | 12.09.2021 | Zenit Izhevsk | - | FK Novosibirsk | 0:1 | ||||
| 11. Jornada | 26.09.2021 | Nosta Novotroitsk | - | FK Novosibirsk | 0:1 | ||||
| 14. Jornada | 09.10.2021 | Dinamo Barnaul | - | FK Novosibirsk | 1:2 | ||||
| 16. Jornada | 20.10.2021 | FK Novosibirsk | - | Irtysh Omsk | 2:0 | ||||
| 20. Jornada | 14.11.2021 | FK Novosibirsk | - | Nosta Novotroitsk | 2:0 |
Rusia