| 16. Jornada | 17.07.2021 | FK Gomel | - | Rukh Brest | 0:0 | ||||
| 17. Jornada | 23.07.2021 | Rukh Brest | - | FK Minsk | 1:0 | ||||
| 18. Jornada | 30.07.2021 | Energetik-BGU Minsk | - | Rukh Brest | 0:2 | ||||
| 20. Jornada | 21.08.2021 | FK Smorgon | - | Rukh Brest | 1:1 | ||||
| 21. Jornada | 27.08.2021 | Rukh Brest | - | Shakhter Soligorsk | 1:0 | ||||
| 22. Jornada | 12.09.2021 | FK Slaviya Mozyr | - | Rukh Brest | 1:1 |  |
|||
| 24. Jornada | 25.09.2021 | Rukh Brest | - | BATE Borisov | 2:2 | ||||
| 25. Jornada | 01.10.2021 | Neman Grodno | - | Rukh Brest | 0:1 | ||||
| 26. Jornada | 17.10.2021 | Rukh Brest | - | Dinamo Minsk | 1:3 |  |
Bielorrusia