| 5. Jornada | 02.03.2021 | Libertad | - | River Plate | 2:1 | ||||
| 8. Jornada | 13.03.2021 | River Plate | - | Club Nacional | 0:0 | ||||
| 10. Jornada | 02.04.2021 | River Plate | - | 12 de Octubre de Itauguá | 0:2 |  |
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| 11. Jornada | 13.04.2021 | Guaraní | - | River Plate | 2:0 | ||||
| 14. Jornada | 04.05.2021 | River Plate | - | Libertad | 1:3 | ||||
| 15. Jornada | 10.05.2021 | Guaireña FC | - | River Plate | 0:0 | ||||
| 16. Jornada | 16.05.2021 | River Plate | - | Cerro Porteño | 1:1 | ||||
| 17. Jornada | 24.05.2021 | Club Nacional | - | River Plate | 0:1 |
Paraguay