| 3. Jornada | 06.08.2021 | Club Necaxa [Sub 20] | - | Cruz Azul [Sub 20] | 1:0 | ||||
| 5. Jornada | 18.08.2021 | Cruz Azul [Sub 20] | - | CF Monterrey [Sub 20] | 2:1 | ||||
| 6. Jornada | 21.08.2021 | Atlético San Luis [Sub 20] | - | Cruz Azul [Sub 20] | 0:0 | ||||
| 7. Jornada | 29.08.2021 | Cruz Azul [Sub 20] | - | CF Pachuca [Sub 20] | 0:0 | ||||
| 10. Jornada | 24.09.2021 | Puebla FC [Sub 20] | - | Cruz Azul [Sub 20] | 0:0 | ||||
| 12. Jornada | 04.10.2021 | Club Tijuana [Sub 20] | - | Cruz Azul [Sub 20] | 0:1 |  |
México