 |
 |
|
|
| 23.09.2021 | 19:00 | CF Pachuca | - | Club Necaxa | 1:1 (1:1) | |
| 24.09.2021 | 16:00 | Puebla FC | - | Cruz Azul | 0:0 (0:0) | |
| 17:00 | FC Juárez | - | Gallos Blancos | 1:1 (0:0) | ||
| 25.09.2021 | 00:45 | Club Tijuana | - | Mazatlán FC | 3:5 (1:4) | |
| 16:00 | Atlas Guadalajara | - | Club León | 2:1 (0:0) | ||
| 16:00 | CF América | - | Deportivo Guadalajara | 1:3 (1:2) | ||
| 16:00 | UANL Tigres | - | Pumas UNAM | 2:1 (1:0) | ||
| 26.09.2021 | 16:00 | Deportivo Toluca | - | Atlético San Luis | 2:0 (0:0) | |
| 17:30 | Santos Laguna | - | CF Monterrey | 4:1 (2:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Toluca | 10 | 6 | 2 | 2 | 17:10 | 7 | 20 |
| 2 |
|
Santos Laguna | 10 | 5 | 3 | 2 | 20:14 | 6 | 18 |
| 3 |
|
Club León | 10 | 5 | 2 | 3 | 12:10 | 2 | 17 |
| 4 |
|
CF América | 10 | 4 | 4 | 2 | 18:14 | 4 | 16 |
| 5 |
|
Atlas Guadalajara | 10 | 5 | 1 | 4 | 13:13 | 0 | 16 |
| 6 |
|
Club Necaxa | 10 | 4 | 3 | 3 | 16:13 | 3 | 15 |
| 7 |
|
Gallos Blancos | 10 | 4 | 3 | 3 | 13:11 | 2 | 15 |
| 8 |
|
Club Tijuana | 10 | 4 | 3 | 3 | 16:15 | 1 | 15 |
| 9 |
|
UANL Tigres | 10 | 4 | 2 | 4 | 13:11 | 2 | 14 |
| 10 |
|
CF Pachuca | 10 | 3 | 5 | 2 | 11:10 | 1 | 14 |
| 11 |
|
Deportivo Guadalajara | 10 | 4 | 2 | 4 | 14:16 | -2 | 14 |
| 12 |
|
Mazatlán FC | 10 | 4 | 2 | 4 | 17:20 | -3 | 14 |
| 13 |
|
Cruz Azul | 10 | 2 | 6 | 2 | 7:7 | 0 | 12 |
| 14 |
|
Puebla FC | 10 | 3 | 3 | 4 | 16:20 | -4 | 12 |
| 15 |
|
Atlético San Luis | 10 | 3 | 2 | 5 | 18:18 | 0 | 11 |
| 16 |
|
CF Monterrey | 10 | 3 | 2 | 5 | 16:16 | 0 | 11 |
| 17 |
|
Pumas UNAM | 10 | 2 | 2 | 6 | 15:22 | -7 | 8 |
| 18 |
|
FC Juárez | 10 | 0 | 3 | 7 | 6:18 | -12 | 3 |
| Playoff |
