 |
 |
|
|
| 22.09.2021 | 16:00 | CF Monterrey | - | Deportivo Toluca | 1:0 (0:0) | |
| 28.09.2021 | 16:00 | Atlas Guadalajara | - | Puebla FC | 3:3 (2:1) | |
| 16:00 | Club Necaxa | - | Club Tijuana | 2:2 (1:0) | ||
| 17:30 | Mazatlán FC | - | FC Juárez | 2:2 (1:1) | ||
| 19:00 | CF Pachuca | - | CF América | 1:2 (1:0) | ||
| 29.09.2021 | 16:00 | Gallos Blancos | - | Deportivo Guadalajara | 1:2 (0:2) | |
| 16:00 | Atlético San Luis | - | UANL Tigres | 2:1 (0:0) | ||
| 03.11.2021 | 18:30 | Cruz Azul | - | Club León | 2:0 (0:0) | |
| 04.11.2021 | 16:00 | Pumas UNAM | - | Santos Laguna | 2:1 (1:1) |
| » Clasificación | En casa | Fuera de casa | 1.ª vuelta | 2.ª vuelta |
| # | Equipo | P | V | E | D | Goles | DG | Pun. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Toluca | 11 | 6 | 2 | 3 | 17:11 | 6 | 20 |
| 2 |
|
CF América | 11 | 5 | 4 | 2 | 20:15 | 5 | 19 |
| 3 |
|
Santos Laguna | 11 | 5 | 3 | 3 | 21:16 | 5 | 18 |
| 4 |
|
Atlas Guadalajara | 11 | 5 | 2 | 4 | 16:16 | 0 | 17 |
| 5 |
|
Club León | 11 | 5 | 2 | 4 | 12:12 | 0 | 17 |
| 6 |
|
Deportivo Guadalajara | 11 | 5 | 2 | 4 | 16:17 | -1 | 17 |
| 7 |
|
Club Necaxa | 11 | 4 | 4 | 3 | 18:15 | 3 | 16 |
| 8 |
|
Club Tijuana | 11 | 4 | 4 | 3 | 18:17 | 1 | 16 |
| 9 |
|
Cruz Azul | 11 | 3 | 6 | 2 | 9:7 | 2 | 15 |
| 10 |
|
Gallos Blancos | 11 | 4 | 3 | 4 | 14:13 | 1 | 15 |
| 11 |
|
Mazatlán FC | 11 | 4 | 3 | 4 | 19:22 | -3 | 15 |
| 12 |
|
Atlético San Luis | 11 | 4 | 2 | 5 | 20:19 | 1 | 14 |
| 13 |
|
CF Monterrey | 11 | 4 | 2 | 5 | 17:16 | 1 | 14 |
| 14 |
|
UANL Tigres | 11 | 4 | 2 | 5 | 14:13 | 1 | 14 |
| 15 |
|
CF Pachuca | 11 | 3 | 5 | 3 | 12:12 | 0 | 14 |
| 16 |
|
Puebla FC | 11 | 3 | 4 | 4 | 19:23 | -4 | 13 |
| 17 |
|
Pumas UNAM | 11 | 3 | 2 | 6 | 17:23 | -6 | 11 |
| 18 |
|
FC Juárez | 11 | 0 | 4 | 7 | 8:20 | -12 | 4 |
| Playoff |
