| 19. Jornada | 12.02.2022 | FK Bregalnica Štip | - | FK Renova | 1:2 | ||||
| 20. Jornada | 20.02.2022 | FK Renova | - | Makedonija GP | 0:1 |  |
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| 21. Jornada | 28.02.2022 | FK Pelister | - | FK Renova | 1:1 | |
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| 22. Jornada | 09.03.2022 | FK Renova | - | KF Shkupi | 0:0 | ||||
| 23. Jornada | 14.03.2022 | FK Renova | - | FK Pelister | 0:0 |  |
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| 25. Jornada | 03.04.2022 | FK Bregalnica Štip | - | FK Renova | 2:2 | ||||
| 26. Jornada | 06.04.2022 | FK Renova | - | Makedonija GP | 0:1 | ||||
| 27. Jornada | 10.04.2022 | KF Shkëndija 79 | - | FK Renova | 1:1 | ||||
| 28. Jornada | 17.04.2022 | FK Renova | - | FK AP Brera Strumica | 0:1 | ||||
| 29. Jornada | 23.04.2022 | KF Shkupi | - | FK Renova | 2:0 | ||||
| 30. Jornada | 01.05.2022 | FK Renova | - | FC Struga | 1:1 | ||||
| 31. Jornada | 04.05.2022 | GFK Tikvesh | - | FK Renova | 0:1 | ||||
| 32. Jornada | 08.05.2022 | FK Renova | - | FK Skopje | 2:0 | ||||
| 33. Jornada | 15.05.2022 | FK Borec | - | FK Renova | 1:5 |  |
Croacia